111-3 Actin and Actin-Associated Proteins

Hirano body filaments contain actin and actin-associated proteins.

Hirano bodies are eosinophilic, rod-shaped intraneuronal inclusions whose frequency increases with age and with Alzheimer's disease. To investigate their composition and possible relationship to the neuronal cytoskeleton, we employed immunocytochemistry and immunoelectronmicroscopy by using antisera to cytoskeletal proteins. The presence of actin, alpha-actinin, vinculin and tropomyosin was dem...

Endothelial Actin-Binding Proteins and Actin

The polymerization of actin. III. Aggregates of nonfilamentous actin and its associated proteins: a storage form of actin

When echinoderm sperm are treated with the detergent Triton X-100 at pH 6.4 in 10 mM phosphate buffer, the membranes are solubilized, but the actin which is located in the periacrosomal region remains as a phase-dense cup. These cups can be isolated free from the flagella and chromatin and can be solubilized by increasing the pH to 8.0 and by changing the ionic strength and type of buffer used....

2122 Actin and actin-binding proteins in proliferative vitreoretinopathy

TITLE: HUMAN FIBROBLASTS PRODUCE AN OPTIMAL PVR EXPERIMENTAL MODEL. AUTHORS: GRACIA-MARTIN M.C., LIBERT J. AFFILIATION: Senior research fellow, Or. Gracia-Martin M.C Prof and Head of Dep., Or. Libert J. Dep. Ophthalmology St. Pierre Hosp., Brussels ABSTRACT: Purpose. Complex tractional retinal detachments show a low percentage of succesful reattachment, due to the development of oroliferative v...

Actin-binding proteins.

Actin is an essential component of the cytoskeleton and plays a crucial role in eukaryotic cells. The actin cytoskeleton functions in the generation and maintenance of cell morphology and polarity, in endocytosis and intracellular trafficking, in contractility, motility and cell division. In cells, the assembly and disassembly of actin filaments, and also their organisation into functional high...